MRI-based biodistribution assessment of holmium-166 poly(L-lactic acid) microspheres after radioembolisation
نویسندگان
چکیده
منابع مشابه
Neutron activation of holmium poly(L-lactic acid) microspheres for hepatic arterial radioembolization: a validation study
Poly(L-lactic acid) microspheres loaded with holmium-166 acetylacetonate (166Ho-PLLA-MS) are a novel microdevice for intra-arterial radio-embolization in patients with unresectable liver malignancies. The neutron activation in a nuclear reactor, in particular the gamma heating, damages the 166Ho-PLLA-MS. The degree of damage is dependent on the irradiation characteristics and irradiation time i...
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Polymers, based on Poly L-lactic acid (L-PLA) and coupled with β-Cyclodextrin (β-CD), have been used for the preparation of microspheres for drug encapsulation. The strategy was based on the modification of the terminal carboxylic group of L-PLA (73.000) by coupling it with a β-CD in the presence of the peptide coupling agents: DCC/HOBT. The degree of functionalisation was found to be 80%. Char...
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ژورنال
عنوان ژورنال: European Radiology
سال: 2012
ISSN: 0938-7994,1432-1084
DOI: 10.1007/s00330-012-2648-2